Surgical excision of pure flat epithelial atypia identified on core needle breast biopsy

Vanessa L Prowler; Jennifer E Joh; Geza Acs; John V Kiluk; Christine Laronga; Nazanin Khakpour; M Catherine Lee

doi:10.1016/j.breast.2014.01.013

Surgical excision of pure flat epithelial atypia identified on core needle breast biopsy

Breast. 2014 Aug;23(4):352-6. doi: 10.1016/j.breast.2014.01.013. Epub 2014 Feb 8.

Authors

Vanessa L Prowler¹, Jennifer E Joh², Geza Acs³, John V Kiluk⁴, Christine Laronga⁴, Nazanin Khakpour⁴, M Catherine Lee⁵

Affiliations

¹ University of South Florida, Department of Surgery, Tampa, FL 33606, USA.
² Hoffberger Breast Center, Mercy Medical Center, Baltimore, MD, USA.
³ Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
⁴ Department of Women's Oncology, Comprehensive Breast Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA; University of South Florida, Department of Surgery, Tampa, FL 33606, USA.
⁵ Department of Women's Oncology, Comprehensive Breast Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA; University of South Florida, Department of Surgery, Tampa, FL 33606, USA. Electronic address: M.Catherine.Lee@moffitt.org.

PMID: 24518220
DOI: 10.1016/j.breast.2014.01.013

Abstract

The biology of flat epithelial atypia (FEA) is still being investigated as its presence becomes more frequent on biopsy specimens. FEA is more commonly associated with malignancy when found in association with ADH, ALH or LCIS. Pure FEA is only upgraded to cancer in 3.2% of patients. Surgical excision of pure FEA found on core needle biopsy results in overtreatment in the vast majority of breast patients and may not be necessary.

Keywords: Atypical ductal hyperplasia; Atypical lobular hyperplasia; Core needle biopsy; Flat epithelial atypia.

MeSH terms

Adult
Aged
Biopsy, Large-Core Needle
Breast / pathology*
Breast / surgery
Breast Neoplasms / pathology*
Carcinoma in Situ / pathology*
Carcinoma, Ductal, Breast / pathology*
Carcinoma, Intraductal, Noninfiltrating / pathology*
Carcinoma, Lobular / pathology*
Epithelial Cells / pathology*
Female
Humans
Hyperplasia / pathology
Hyperplasia / surgery
Middle Aged
Neoplasm Grading