Abstract
FK506 is the most potent immunosuppressive agent known. Its toxicity is substantial in dogs, minor in rats, and unknown in subhuman primates. In small doses that are nontoxic even in dogs, it can be used in synergistic combination with cyclosporine, steroids, and presumably in other drugs.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Cyclosporins / administration & dosage
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Dogs
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Drug Evaluation, Preclinical
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Drug Therapy, Combination
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Graft Rejection / drug effects*
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Heart Transplantation
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Immunosuppressive Agents / therapeutic use*
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Immunosuppressive Agents / toxicity
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Kidney Diseases / chemically induced
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Kidney Transplantation
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Liver Transplantation
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Prednisone / administration & dosage
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Pyridines / administration & dosage
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Pyridines / therapeutic use
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Pyridines / toxicity
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Rats
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Rats, Inbred ACI / immunology
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Rats, Inbred BN / immunology
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Rats, Inbred Lew / immunology
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Tacrolimus
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Transplantation, Heterologous
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Transplantation, Homologous
Substances
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Cyclosporins
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Immunosuppressive Agents
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Pyridines
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Prednisone
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Tacrolimus