EMT twists the road to PI3K

Cancer Discov. 2014 Feb;4(2):149-51. doi: 10.1158/2159-8290.CD-13-1030.

Abstract

Epithelial-to-mesenchymal transition (EMT) is important for many developmental events and has been linked to tumor dissemination and therapeutic resistance. Salt and colleagues identify how EMT affects how proliferation signals flow to phosphoinositide 3-kinase in non-small cell lung cancer.

Publication types

  • Comment

MeSH terms

  • Epithelial-Mesenchymal Transition*
  • Humans
  • Phosphatidylinositol 3-Kinases / metabolism*
  • Signal Transduction*

Substances

  • Phosphatidylinositol 3-Kinases