Abstract
Three new C₁₉-diterpenoid alkaloids, ducloudines C (1), D (2), and E (3), were isolated from the roots of Aconitum duclouxii. Their structures were established on the basis of extensive spectroscopic analyses. Ducloudine C (1) is the first aconitine-type C₁₉-diterpenoid alkaloid with a C=O group at C-3 and a C=C bond between C-1 and C-2. All compounds were tested for their biological activities against one pathogenic fungi and two pathogenic bacteria.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aconitine / chemistry
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Aconitine / isolation & purification
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Aconitum / chemistry*
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Alkaloids / chemistry
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology
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Diterpenes / chemistry
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Diterpenes / isolation & purification*
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Diterpenes / pharmacology
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology
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Microbial Sensitivity Tests
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Plant Roots / chemistry
Substances
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Alkaloids
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Diterpenes
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Drugs, Chinese Herbal
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ducloudine C
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ducloudine D
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ducloudine E
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Aconitine