Three new diterpenoid alkaloids from the roots of Aconitum duclouxii

J Asian Nat Prod Res. 2014;16(4):345-50. doi: 10.1080/10286020.2014.881802. Epub 2014 Feb 5.

Abstract

Three new C₁₉-diterpenoid alkaloids, ducloudines C (1), D (2), and E (3), were isolated from the roots of Aconitum duclouxii. Their structures were established on the basis of extensive spectroscopic analyses. Ducloudine C (1) is the first aconitine-type C₁₉-diterpenoid alkaloid with a C=O group at C-3 and a C=C bond between C-1 and C-2. All compounds were tested for their biological activities against one pathogenic fungi and two pathogenic bacteria.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aconitine / chemistry
  • Aconitine / isolation & purification
  • Aconitum / chemistry*
  • Alkaloids / chemistry
  • Alkaloids / isolation & purification*
  • Alkaloids / pharmacology
  • Diterpenes / chemistry
  • Diterpenes / isolation & purification*
  • Diterpenes / pharmacology
  • Drugs, Chinese Herbal / chemistry
  • Drugs, Chinese Herbal / isolation & purification*
  • Drugs, Chinese Herbal / pharmacology
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Plant Roots / chemistry

Substances

  • Alkaloids
  • Diterpenes
  • Drugs, Chinese Herbal
  • ducloudine C
  • ducloudine D
  • ducloudine E
  • Aconitine