The effect of hyperinsulinemia and hyperglycemia on endothelial function in pregnant patients with type-2 diabetes

Reena Khurana; Graydon S Meneilly; Kenneth Lim; David Thompson

doi:10.1016/j.diabres.2013.12.053

The effect of hyperinsulinemia and hyperglycemia on endothelial function in pregnant patients with type-2 diabetes

Diabetes Res Clin Pract. 2014 Mar;103(3):e11-3. doi: 10.1016/j.diabres.2013.12.053. Epub 2014 Jan 15.

Authors

Reena Khurana¹, Graydon S Meneilly², Kenneth Lim³, David Thompson¹

Affiliations

¹ The Division of Endocrinology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
² The Division of Geriatric Medicine, Department of Medicine, University of British Columbia, Vancouver, BC, Canada. Electronic address: meneilly@mail.ubc.ca.
³ The Division of Perinatology, Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, BC, Canada.

PMID: 24485854
DOI: 10.1016/j.diabres.2013.12.053

Abstract

We studied endothelial function (flow mediated vasodilation, FMD) during hyperinsulinemia and hyperglycemia in pregnant women with type-2 diabetes, in the second and third trimester. We found that hyperglycemia reduces FMD in late pregnancy.

Keywords: Endothelial function; Glucose clamp; Pregnancy; Type-2 diabetes.

MeSH terms

Adult
Diabetes Mellitus, Type 2 / complications
Diabetes Mellitus, Type 2 / physiopathology*
Endothelium, Vascular / pathology*
Female
Humans
Hyperglycemia / complications
Hyperglycemia / physiopathology*
Hyperinsulinism / complications
Hyperinsulinism / physiopathology*
Male
Pregnancy
Pregnancy Trimester, Second
Pregnancy Trimester, Third
Pregnancy in Diabetics / physiopathology*
Vasodilation