Cisplatin binds to human copper chaperone Cox17: the mechanistic implication of drug delivery to mitochondria

Chem Commun (Camb). 2014 Mar 11;50(20):2667-9. doi: 10.1039/c3cc48847k.

Abstract

Cox17 facilitates the platinum accumulation in mitochondria, which contributes to the overall cytotoxicity of cisplatin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / metabolism
  • Antineoplastic Agents / pharmacology
  • Carrier Proteins / metabolism*
  • Cisplatin / metabolism
  • Cisplatin / pharmacology*
  • Copper Transport Proteins
  • Drug Delivery Systems
  • HeLa Cells
  • Humans
  • Mitochondria / drug effects*

Substances

  • Antineoplastic Agents
  • COX17 protein, human
  • Carrier Proteins
  • Copper Transport Proteins
  • Cisplatin