Uveal melanoma: evaluation of extrascleral extension using thin-section MR of the eye with surface coils

Radiol Med. 2014 Oct;119(10):775-83. doi: 10.1007/s11547-014-0388-x. Epub 2014 Jan 28.

Abstract

Purpose: This study was done to evaluate the role of high-resolution magnetic resonance (MR) imaging with special surface coils in selecting the correct therapeutic approach (eye enucleation or follow-up) in patients with suspected extrascleral extension of uveal melanoma.

Materials and methods: This prospective study involved 12 patients with suspected extrascleral extension of uveal melanoma on orbital ultrasonography. All patients were studied with thin-section MR imaging of the eye using surface coils.

Results: High-resolution MR imaging of the eye excluded extrascleral extension of disease in 8/12 patients: in 4/8 cases it revealed vascular ectasia and in the other 4/8 cases the linear hypointensity of the sclera was unbroken. Seven of these eight patients were followed up by ultrasound, which showed stability of melanoma for at least 2 years, while the last patient underwent enucleation, and the histological examination confirmed the MR diagnosis. In 4/12 patients, high-resolution MR suggested a diagnosis of extrascleral extension of melanoma, which was confirmed at histological examination after enucleation.

Conclusion: High-resolution MR imaging of the eye with surface coils allowed us to evaluate extrascleral extension of uveal melanoma and choose the correct therapeutic approach, avoiding unnecessary enucleation in 7/12 patients.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Amplifiers, Electronic*
  • Equipment Design
  • Eye Enucleation
  • Female
  • Humans
  • Image Enhancement / instrumentation
  • Magnetic Resonance Imaging / instrumentation*
  • Magnetic Resonance Imaging / methods
  • Male
  • Melanoma / pathology*
  • Melanoma / surgery
  • Middle Aged
  • Neoplasm Invasiveness
  • Predictive Value of Tests
  • Prospective Studies
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Uveal Melanoma
  • Uveal Neoplasms / pathology*
  • Uveal Neoplasms / surgery