The detrimental role of glial acidification during ischemia

Steven A Sloan; Ben A Barres

doi:10.1016/j.neuron.2013.12.032

The detrimental role of glial acidification during ischemia

Neuron. 2014 Jan 22;81(2):221-3. doi: 10.1016/j.neuron.2013.12.032.

Authors

Steven A Sloan¹, Ben A Barres²

Affiliations

¹ Department of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305-5125, USA. Electronic address: ssloan1@stanford.edu.
² Department of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305-5125, USA.

Abstract

In this issue of Neuron, Beppu et al. (2014) demonstrate that glial acidification during ischemia contributes to neurotoxicity. Using a suite of in vivo optogenetic tools, the authors are able to exacerbate or attenuate neuronal damage during ischemia with glial acidification or alkalization, respectively.

Publication types

Comment

MeSH terms

Acidosis*
Animals
Glutamic Acid / metabolism*
Hypoxia-Ischemia, Brain / complications*
Neuroglia / metabolism*
Optogenetics*

Substances

Glutamic Acid

Grants and funding

F30 MH106261/MH/NIMH NIH HHS/United States