Methicillin-susceptible Staphylococcus aureus clonal complex 398: high prevalence and geographical heterogeneity in bone and joint infection and nasal carriage

F Valour; J Tasse; S Trouillet-Assant; J-P Rasigade; B Lamy; E Chanard; P Verhoeven; J-W Decousser; H Marchandin; M Bès; C Chidiac; F Vandenesch; T Ferry; F Laurent; Lyon Bone and Joint Infection study group

doi:10.1111/1469-0691.12567

Methicillin-susceptible Staphylococcus aureus clonal complex 398: high prevalence and geographical heterogeneity in bone and joint infection and nasal carriage

Clin Microbiol Infect. 2014 Oct;20(10):O772-5. doi: 10.1111/1469-0691.12567. Epub 2014 Mar 6.

Authors

F Valour¹, J Tasse, S Trouillet-Assant, J-P Rasigade, B Lamy, E Chanard, P Verhoeven, J-W Decousser, H Marchandin, M Bès, C Chidiac, F Vandenesch, T Ferry, F Laurent; Lyon Bone and Joint Infection study group

Collaborators

Lyon Bone and Joint Infection study group:
F Ader, F Biron, A Boibieux, A Bouaziz, E Braun, C Chidiac, F Daoud, T Ferry, J Karsenty, J Lippman, P Miailhes, T Perpoint, D Peyramond, M-P Vallat, F Valour, C Barrey, M-H Fessy, O Guyen, C Lienhart, S Lustig, P Neyret, F Trouillet, G Vaz, F Laurent, J-P Rasigade, F Vandenesch, E Deshayes, F Giammarile, M Janier, I Morelec, M-C Gagnieu, S Goutelle, M Tod, M Martinez

Affiliation

¹ Bacteriology Department, Groupement Hospitalier Nord, Hospices Civils de Lyon, Lyon, France; Infectious Diseases Department, Hospices Civils de Lyon, Lyon, France; International Centre for Research in Infectious Diseases, INSERM U1111, Université Claude Bernard Lyon 1, Lyon, France.

PMID: 24461054
DOI: 10.1111/1469-0691.12567

Abstract

The prevalence of clonal complex (CC) 398 methicillin-susceptible Staphylococcus aureus (MSSA) was unexpectedly high among bone and joint infections (BJIs) and nasal-colonizing isolates in France, with surprising geographical heterogeneity. With none of the major, most-known staphylococcal virulence genes, MSSA CC398 BJI was associated with lower biological inflammatory syndrome and lower treatment failure rates.

Keywords: Clonal complex 398; bone and joint infection; methicillin-susceptible Staphylococcus aureus; molecular epidemiology; nasal carriage; virulence factors.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Arthritis, Infectious / epidemiology
Arthritis, Infectious / microbiology*
Bone Diseases, Infectious / epidemiology
Bone Diseases, Infectious / microbiology*
Carrier State / microbiology
Female
Humans
Male
Methicillin-Resistant Staphylococcus aureus / isolation & purification
Middle Aged
Nose / microbiology*
Prevalence
Retrospective Studies
Staphylococcal Infections / epidemiology
Staphylococcal Infections / microbiology*
Staphylococcus aureus / classification*
Staphylococcus aureus / isolation & purification*