Abstract
The immunosuppressive agent FK permitted increased kidney transplant survival in dogs over a wide dose range, but with weight loss and manifold evidence of toxicity. The best use of FK at low doses was in combination with CyA and Pred.
Publication types
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Comparative Study
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Body Weight / drug effects
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Cyclosporins / administration & dosage
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Cyclosporins / therapeutic use*
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Dogs
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Drug Evaluation, Preclinical
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Drug Synergism
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Drug Therapy, Combination
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Graft Rejection / drug effects
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Immunosuppressive Agents / administration & dosage
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Immunosuppressive Agents / therapeutic use*
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Immunosuppressive Agents / toxicity
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Kidney Transplantation*
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Prednisolone / administration & dosage
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Prednisolone / therapeutic use*
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Pyridines / administration & dosage
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Pyridines / therapeutic use
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Pyridines / toxicity
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Tacrolimus
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Vomiting / chemically induced
Substances
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Cyclosporins
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Immunosuppressive Agents
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Pyridines
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Prednisolone
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Tacrolimus