Functional connectivity of resting state EEG and symptom severity in patients with post-traumatic stress disorder

Abstract

Objectives: Post-traumatic stress disorder (PTSD) is thought to be a brain network disorder. This study aimed to examine the resting-state functional connectivity (FC) in patients with PTSD.

Methods: Thirty-three PTSD patients and 30 age- and gender-matched healthy controls were recruited. Symptom severity of the PTSD patients was assessed, and 62-channel EEG was measured. EEGs were recorded during the resting state, with the eyes closed. Three nodal network measures to assess nodal centrality [nodal degree (Dnodal; connection strength), nodal efficiency (Enodal; communication efficiency), and betweenness centrality (BC; connection centrality)] were calculated in the delta, theta, alpha, beta, and gamma bands.

Results: Dnodal and Enodal of the beta and gamma bands were decreased in PTSD patients compared to healthy controls. These decreased nodal centrality values were observed primarily at the frontocentral electrodes. In addition, Dnodal of the beta and gamma bands was significantly correlated with depressive symptoms and increased arousal symptoms, respectively. Enodal of the beta and gamma bands was significantly correlated with re-experience, increased arousal, and the severity and frequency of general PTSD symptoms.

Conclusion: Compared to controls, patients with PTSD were found to have decreased resting-state FC, and these FC measures were significantly correlated with PTSD symptom severity. Our results suggest that resting-state FC could be a useful biomarker for PTSD.

Keywords: Biomarker; EEG; Functional connectivity; PTSD; Resting state.