Homologous Canavalia lectins elicit different patterns of antinociceptive responses

Nilson Vieira Pinto; Cláudia Ferreira Santos; Benildo Sousa Cavada; Kyria Santiago do Nascimento; Francisco Nascimento Pereira Junior; Alana de Freitas Pires; Ana Maria Sampaio Assreuy

Homologous Canavalia lectins elicit different patterns of antinociceptive responses

Nat Prod Commun. 2013 Nov;8(11):1621-4.

Authors

Nilson Vieira Pinto¹, Cláudia Ferreira Santos¹, Benildo Sousa Cavada², Kyria Santiago do Nascimento², Francisco Nascimento Pereira Junior², Alana de Freitas Pires¹, Ana Maria Sampaio Assreuy¹

Affiliations

¹ Instituto Superior de Ciências Biomédicas, Universidade Estadual do Cearcá, Av. Paranjana 1700, 60.740-000, Fortaleza-CE-Brasil.
² Departamento de Bioquimíca e Biologia Molecular, Universidade Federal do Ceará, Av. Mister Hull s/n Bloco 907, 60.445-970, Fortaleza-CE-Brasil.

PMID: 24427956

Abstract

Canavalia gladiata (CGL), C. maritima (ConM) and C. brasiliensis (ConBr) lectins were evaluated in nociception models. ConBr inhibited first (32%) and second (100%) phases of the formalin test; CGL inhibited only the first (74%) and ConM only the second (59%) phase. Hypernociception evaluated in the Von Frey test was inhibited by ConM (55%), CGL (41%) and ConBr (38%). Acetic acid-induced abdominal writhing was reduced by ConBr (66%), CGL (52%) and ConM (60%). ConBr and CGL effects were reversed by the lectin association with its ligand sugar. The antinociceptive activity of the structural homologous lectins was differentiated by potency, efficacy and mechanisms.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Analgesics / pharmacology*
Animals
Male
Mice
Motor Activity / drug effects
Plant Lectins / pharmacology*

Substances

Analgesics
Plant Lectins
lectin, Canavalia