Epidermal cyst is the most commonly observed cutaneous tumor. It usually involves the scalp, neck, face, back, and trunk. A commonly seen epidermal cyst is usually a slow-growing tumor of a diameter of 1-2 cm. Cysts with a diameter of more than 5 cm have rarely been reported in the literature. Herein we report a case of a giant epidermal cyst localized in the scalp of the occipital area, diagnostic problems and therapeutic proceedings.