Synaptic plasticity and the Warburg effect

Pierre J Magistretti

doi:10.1016/j.cmet.2013.12.012

Synaptic plasticity and the Warburg effect

Cell Metab. 2014 Jan 7;19(1):4-5. doi: 10.1016/j.cmet.2013.12.012.

Author

Pierre J Magistretti¹

Affiliation

¹ Brain Mind Institute, EPFL, Station 19, CH-1015 Lausanne, Switzerland; Center for Psychiatric Neuroscience, CHUV-UNIL, CH-1008 Prilly-Lausanne, Switzerland; Division of Biological and Environmental Sciences and Engineering, KAUST, Thuwal 23955-6900, Kingdom of Saudi Arabia. Electronic address: pierre.magistretti@epfl.ch.

PMID: 24411936
DOI: 10.1016/j.cmet.2013.12.012

Abstract

Functional brain imaging studies show that in certain brain regions glucose utilization exceeds oxygen consumption, indicating the predominance of aerobic glycolysis. In this issue, Goyal et al. (2014) report that this metabolic profile is associated with an enrichment in the expression of genes involved in synaptic plasticity and remodeling processes.

Publication types

Comment

MeSH terms

Brain / metabolism*
Gene Expression Regulation, Developmental*
Glycolysis / genetics*
Humans