Draft genomes of three Antarctic Psychrobacter strains producing antimicrobial compounds against Burkholderia cepacia complex, opportunistic human pathogens

Marco Fondi; Valerio Orlandini; Elena Perrin; Isabel Maida; Emanuele Bosi; Maria Cristiana Papaleo; Luigi Michaud; Angelina Lo Giudice; Donatella de Pascale; Maria Luisa Tutino; Pietro Liò; Renato Fani

doi:10.1016/j.margen.2013.12.009

Draft genomes of three Antarctic Psychrobacter strains producing antimicrobial compounds against Burkholderia cepacia complex, opportunistic human pathogens

Mar Genomics. 2014 Feb:13:37-8. doi: 10.1016/j.margen.2013.12.009. Epub 2014 Jan 5.

Authors

Affiliations

¹ Laboratory of Microbial and Molecular Evolution, Department of Biology, University of Florence, Via Madonna del Piano 6, 50019 Sesto Fiorentino, Firenze, Italy; Computer Laboratory, Cambridge University, William Gates Building 15, JJ Thomson Avenue, Cambridge, United Kingdom. Electronic address: marco.fondi@unifi.it.
² Laboratory of Microbial and Molecular Evolution, Department of Biology, University of Florence, Via Madonna del Piano 6, 50019 Sesto Fiorentino, Firenze, Italy; Institute of Protein Biochemistry, National Research Council, Via P. Castellino, 111 I-80134 Naples, Italy.
³ Laboratory of Microbial and Molecular Evolution, Department of Biology, University of Florence, Via Madonna del Piano 6, 50019 Sesto Fiorentino, Firenze, Italy.
⁴ Department of Biological and Environmental Sciences (DiSBA-CIBAN), University of Messina, Viale Ferdinando Stagno d'Alcontrès 31, I-98166 Messina, Italy.
⁵ Institute of Protein Biochemistry, National Research Council, Via P. Castellino, 111 I-80134 Naples, Italy.
⁶ Department of Chemical Sciences, University of Naples Federico II, Complesso Universitario M. S. Angelo, Via Cintia, I-80126 Naples, Italy.
⁷ Computer Laboratory, Cambridge University, William Gates Building 15, JJ Thomson Avenue, Cambridge, United Kingdom.

PMID: 24401162
DOI: 10.1016/j.margen.2013.12.009

Abstract

Herein we present the draft genomes of three Psychrobacter strains isolated from Antarctic sponges and able to inhibit the growth of bacteria belonging to the Burkholderia cepacia complex, responsible for infections of the respiratory system in patients affected by Cystic Fibrosis. The comparative analysis of the annotated genomes of these Psychrobacter strains highlighted their differences in terms of overall genomic content (e.g. shared gene sets) and allowed the identification of gene clusters hypothetically involved in the biosynthesis of antimicrobial compounds.

Keywords: Antarctic bacteria; Burkholderia infections; Comparative genomics; Genomics.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antarctic Regions
Anti-Bacterial Agents / analysis*
Anti-Bacterial Agents / isolation & purification
Anti-Bacterial Agents / pharmacology
Base Sequence
Burkholderia cepacia complex / drug effects*
Contig Mapping
Genome, Bacterial / genetics*
Genomics
Molecular Sequence Annotation
Molecular Sequence Data
Phylogeny
Porifera / microbiology*
Psychrobacter / chemistry*
Psychrobacter / classification
Psychrobacter / genetics*
Sequence Analysis, DNA
Species Specificity

Substances

Anti-Bacterial Agents