Heat-shock protein-70 and regulatory T cell-mediated protection from ischemic injury

Kidney Int. 2014 Jan;85(1):5-7. doi: 10.1038/ki.2013.304.

Abstract

Heat preconditioning induces heat-shock protein-70 upregulation and protects from renal ischemia/reperfusion injury. Kim et al. report that heat-shock protein-70 and regulatory T cells play a key role in protective heat preconditioning. This work reinforces the utility of inducing heat-shock protein-70 expression by pharmacological agents as a novel therapy for the prevention and treatment of ischemic kidney injury.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Acute Kidney Injury / immunology*
  • Animals
  • HSP70 Heat-Shock Proteins / physiology*
  • Male
  • Reperfusion Injury / immunology*
  • T-Lymphocytes, Regulatory / physiology*

Substances

  • HSP70 Heat-Shock Proteins