Novel TP53 gene mutation and correlation with p53 immunohistochemistry in a mixed epithelial carcinoma of the endometrium

Andrew B Sholl; Dara L Aisner; Kian Behbakht; Miriam D Post

doi:10.1016/j.gynor.2012.10.005

Novel TP53 gene mutation and correlation with p53 immunohistochemistry in a mixed epithelial carcinoma of the endometrium

Gynecol Oncol Case Rep. 2012 Oct 26:3:11-3. doi: 10.1016/j.gynor.2012.10.005. eCollection 2012.

Authors

Andrew B Sholl¹, Dara L Aisner², Kian Behbakht³, Miriam D Post²

Affiliations

¹ University of Colorado, Department of Pathology, USA ; MD Anderson Cancer Center, Department of Pathology, USA.
² University of Colorado, Department of Pathology, USA.
³ University of Colorado, Department of Obstetrics and Gynecology, USA.

Abstract

► We examine the correlation between p53 immunohistochemistry and TP53 gene mutation status in a mixed epithelial endometrial carcinoma. ► We describe a novel R306* (c.916C > T) mutation in exon 8 of the TP53 gene. ► We propose that the distinction between Type I and Type II endometrial carcinomas may be more fluid than previously believed.

Keywords: Endometrioid carcinoma; Mixed epithelial carcinoma; Serous carcinoma; TP53 gene; p53 immunohistochemistry.