South African amaXhosa patients with atopic dermatitis have decreased levels of filaggrin breakdown products but no loss-of-function mutations in filaggrin

J Allergy Clin Immunol. 2014 Jan;133(1):280-2.e1-2. doi: 10.1016/j.jaci.2013.09.053.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Carboxylic Acids / chemistry
  • Carboxylic Acids / metabolism
  • Child
  • Child, Preschool
  • DNA Mutational Analysis
  • Dermatitis, Atopic / epidemiology
  • Dermatitis, Atopic / genetics*
  • Epidermis / metabolism*
  • Female
  • Filaggrin Proteins
  • Genetic Association Studies
  • Genetic Predisposition to Disease
  • Humans
  • Infant
  • Intermediate Filament Proteins / chemistry
  • Intermediate Filament Proteins / genetics*
  • Male
  • Mutation, Missense / genetics
  • Polymorphism, Genetic
  • Proteolysis
  • Pyrrolidinones / chemistry
  • Pyrrolidinones / metabolism
  • Risk
  • South Africa
  • Urocanic Acid / chemistry
  • Urocanic Acid / metabolism
  • Young Adult

Substances

  • Carboxylic Acids
  • FLG protein, human
  • Filaggrin Proteins
  • Intermediate Filament Proteins
  • Pyrrolidinones
  • Urocanic Acid