Interaction of stable colloidal nanoparticles with cellular membranes

Morteza Mahmoudi; Jie Meng; Xue Xue; Xing Jie Liang; Masoud Rahman; Christian Pfeiffer; Raimo Hartmann; Pilar Rivera Gil; Beatriz Pelaz; Wolfgang J Parak; Pablo Del Pino; Susana Carregal-Romero; Antonios G Kanaras; Subramanian Tamil Selvan

doi:10.1016/j.biotechadv.2013.11.012

Interaction of stable colloidal nanoparticles with cellular membranes

Biotechnol Adv. 2014 Jul-Aug;32(4):679-92. doi: 10.1016/j.biotechadv.2013.11.012. Epub 2013 Dec 19.

Authors

Affiliations

¹ Department of Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran; Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
² Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanosciences and Technology of China, Beijing 100190, China.
³ Department of Chemical Engineering and Materials Science, University of California Davis, CA 95616, USA.
⁴ Fachbereich Physik, Philipps University of Marburg, Renthof 7, D-35037 Marburg, Germany.
⁵ Fachbereich Physik, Philipps University of Marburg, Renthof 7, D-35037 Marburg, Germany; CIC biomaGUNE, Paseo Miramón 182, 20009 San Sebastián, Spain.
⁶ Fachbereich Physik, Philipps University of Marburg, Renthof 7, D-35037 Marburg, Germany; Andalusian Center for Nanomedicine and Biotechnology (BIONAND), Andalusian Technological Park, C/Severo Ochoa, 35, 29590 Campanillas, Málaga, Spain.
⁷ Institute for Life Sciences, Physics and Astronomy, Faculty of Physical and Applied Sciences, University of Southampton, Highfield, Southampton SO17, 1BJ, United Kingdom.
⁸ A*STAR Institute of Materials Research and Engineering (IMRE), 3 Research Link, Singapore 117602, Singapore; National University of Singapore, Division of Bioengineering, Faculty of Engineering, 7 Engineering Drive 1, Singapore 117576, Singapore. Electronic address: subramaniant@imre.a-star.edu.sg.

PMID: 24361955
DOI: 10.1016/j.biotechadv.2013.11.012

Abstract

Due to their ultra-small size, inorganic nanoparticles (NPs) have distinct properties compared to the bulk form. The unique characteristics of NPs are broadly exploited in biomedical sciences in order to develop various methods of targeted drug delivery, novel biosensors and new therapeutic pathways. However, relatively little is known in the negotiation of NPs with complex biological environments. Cell membranes (CMs) in eukaryotes have dynamic structures, which is a key property for cellular responses to NPs. In this review, we discuss the current knowledge of various interactions between advanced types of NPs and CMs.

Keywords: Cell membrane; Colloid; Nanoparticle; Protein corona; Receptor; Targeted delivery.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Biosensing Techniques
Blood-Brain Barrier
Cell Membrane / drug effects
Cell Membrane / metabolism
Cellular Structures / metabolism
Colloids / chemistry*
Drug Delivery Systems
Fever
Genetic Therapy
Humans
Nanomedicine / methods
Nanoparticles / chemistry*
Nanotechnology / methods*
Proteins / chemistry
Surface Properties

Substances

Colloids
Proteins