Abstract
A novel formal asymmetric synthesis of (-)-triptonide and (-)-triptolide, featuring a new alternative access to their known key intermediate 4, has been achieved through two synthetic routes in 9 steps with 13.6% total yield and 10 steps with 18.5% overall yield, respectively. This synthesis is scalable and hence has high potential for application to further synthetic elaboration and biologic investigation on such natural products.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Catalysis
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Chemistry Techniques, Synthetic
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Diterpenes / chemical synthesis*
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Diterpenes / chemistry*
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Epoxy Compounds / chemical synthesis
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Epoxy Compounds / chemistry
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Models, Molecular
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Molecular Conformation
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Phenanthrenes / chemical synthesis*
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Phenanthrenes / chemistry*
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Stereoisomerism
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Substrate Specificity
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Triterpenes / chemical synthesis*
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Triterpenes / chemistry*
Substances
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Diterpenes
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Epoxy Compounds
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Phenanthrenes
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Triterpenes
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triptolide
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triptonide