Activation of a photodissociative ruthenium complex by triplet-triplet annihilation upconversion in liposomes

Sven H C Askes; Azadeh Bahreman; Sylvestre Bonnet

doi:10.1002/anie.201309389

Activation of a photodissociative ruthenium complex by triplet-triplet annihilation upconversion in liposomes

Angew Chem Int Ed Engl. 2014 Jan 20;53(4):1029-33. doi: 10.1002/anie.201309389. Epub 2013 Dec 11.

Authors

Sven H C Askes¹, Azadeh Bahreman, Sylvestre Bonnet

Affiliation

¹ Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden (The Netherlands).

PMID: 24339049
DOI: 10.1002/anie.201309389

Abstract

Liposomes capable of generating photons of blue light in situ by triplet-triplet annihilation upconversion of either green or red light, were prepared. The red-to-blue upconverting liposomes were capable of triggering the photodissociation of ruthenium polypyridyl complexes from PEGylated liposomes using a clinical grade photodynamic therapy laser source (630 nm).

Keywords: chemotherapy; liposomes; photochemistry; prodrug; ruthenium.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Lasers
Liposomes / chemistry*
Molecular Structure
Organometallic Compounds / chemistry*
Photochemical Processes
Pyridines / chemistry
Ruthenium / chemistry*

Substances

Liposomes
Organometallic Compounds
Pyridines
Ruthenium