Synthesis of silk fibroin micro- and submicron spheres using a co-flow capillary device

Alexander N Mitropoulos; Giovanni Perotto; Sunghwan Kim; Benedetto Marelli; David L Kaplan; Fiorenzo G Omenetto

doi:10.1002/adma.201304244

Synthesis of silk fibroin micro- and submicron spheres using a co-flow capillary device

Adv Mater. 2014 Feb;26(7):1105-10. doi: 10.1002/adma.201304244. Epub 2013 Dec 12.

Authors

Alexander N Mitropoulos¹, Giovanni Perotto, Sunghwan Kim, Benedetto Marelli, David L Kaplan, Fiorenzo G Omenetto

Affiliation

¹ Department of Biomedical Engineering, Tufts University, 4 Colby St., Medford, MA, 02155, USA.

PMID: 24339048
DOI: 10.1002/adma.201304244

Abstract

A custom-made co-flow capillary device is used to synthesize monodisperse silk fibroin micro- and submicron-spheres with diameters tunable over a wide range of sizes. A model drug release is examined and control of degradation kinetics is obtained by changing sphere diameter.

Keywords: microfluidics; microspheres; nanoparticles; silk.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.