Rational design of polyion complex nanoparticles to overcome cisplatin resistance in cancer therapy

Adv Mater. 2014 Feb 12;26(6):931-6. doi: 10.1002/adma.201303360. Epub 2013 Dec 16.

Abstract

Rationally designed PIC nanoparticles as next-generation delivery system: we have developed a core-shell-corona PIC nanoparticle (⊕) NP/Pt@PPC-DA as a next-generation delivery system. (⊕) NP/Pt@PPC-DA exhibits prolonged circulation and enhanced drug accumulation in tumors. Subsequently, tumor pH leads to the release of (⊕) NP/Pt, which facilitates cellular uptake followed by rapid intracellular cisplatin release. Using this delivery strategy cisplatin-resistant tumor growth in a murine xenograft model has been successfully suppressed.

Keywords: PIC nanoparticles; cisplatin resistance; drug delivery; tumor pH-responsive.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / drug therapy
  • Adenocarcinoma / metabolism
  • Adenocarcinoma / pathology
  • Animals
  • Antineoplastic Agents / administration & dosage*
  • Antineoplastic Agents / blood
  • Antineoplastic Agents / chemistry
  • Cell Line, Tumor
  • Cisplatin / administration & dosage*
  • Cisplatin / blood
  • Cisplatin / chemistry
  • Drug Resistance, Neoplasm*
  • Humans
  • Hydrogen-Ion Concentration
  • Lung Neoplasms / drug therapy
  • Lung Neoplasms / metabolism
  • Lung Neoplasms / pathology
  • Mice
  • Mice, Nude
  • Nanoconjugates* / administration & dosage
  • Nanoconjugates* / chemistry
  • Platinum / chemistry
  • Platinum / metabolism
  • Prodrugs / administration & dosage
  • Prodrugs / chemistry
  • Prodrugs / metabolism
  • Xenograft Model Antitumor Assays

Substances

  • Antineoplastic Agents
  • Nanoconjugates
  • Prodrugs
  • Platinum
  • Cisplatin