Synergistic Au/Ga catalysis in ambient Nakamura reaction

Org Lett. 2014 Jan 3;16(1):306-9. doi: 10.1021/ol403337u. Epub 2013 Dec 9.

Abstract

The gold-catalyzed intermolecular addition of 1,3-dicarbonyl compounds to unactivated 1-alkynes (Nakamura reaction) is achieved at room temperature for the first time through synergistic gold/gallium catalysis. The developed system is highly efficient with a gold catalyst loading that can be as low as 500 ppm.