Abstract
Targeted cell ablation has proven to be a valuable approach to study in vivo cell functions during organogenesis, tissue homeostasis, and regeneration. Over the last two decades, various approaches have been developed to refine the control of cell ablation. In this review, we give an overview of the distinct genetic tools available for targeted cell ablation, with a particular emphasis on their respective specificity.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Apoptosis / genetics*
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Diphtheria Toxin / genetics*
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Diphtheria Toxin / metabolism
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Eukaryotic Initiation Factor-3 / genetics
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Eukaryotic Initiation Factor-3 / metabolism
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Genes, Transgenic, Suicide / genetics*
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Homeostasis / genetics
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Humans
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Molecular Biology / methods
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Organogenesis / genetics*
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Regeneration / genetics
Substances
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Diphtheria Toxin
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Eukaryotic Initiation Factor-3
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EIF3I protein, human