Fluoromethylated derivatives of carnitine biosynthesis intermediates--synthesis and applications

Chem Commun (Camb). 2014 Feb 7;50(10):1175-7. doi: 10.1039/c3cc47581f.

Abstract

A convenient method for the synthesis of fluoromethylated carnitine biosynthesis intermediates, i.e. fluorinated derivatives of γ-butyrobetaine and trimethyllysine, is described. The fluoromethylated probes were useful in both in vitro and cell based assays employing (19)F NMR and LC-MS analyses.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carnitine / chemistry*
  • Cell Line
  • Escherichia
  • Fluorescent Dyes / chemical synthesis
  • Fluorescent Dyes / chemistry
  • Fluorine / chemistry*
  • Humans
  • Methylation
  • Molecular Structure

Substances

  • Fluorescent Dyes
  • Fluorine
  • Carnitine