Inducing cellular aging: enabling neurodegeneration-in-a-dish

Cell Stem Cell. 2013 Dec 5;13(6):635-6. doi: 10.1016/j.stem.2013.11.017.

Abstract

The immaturity of neurons differentiated from human induced pluripotent stem cells (hiPSCs) presents difficulties for modeling late-onset neurodegenerative disorders such as Parkinson's disease. Now, Miller et al. (2013) provide a strategy for inducing aging-related phenotypes in hiPSC-derived neurons, enabling in vitro study of late-onset neurodegenerative diseases.

Publication types

  • Comment

MeSH terms

  • Aging / pathology*
  • Animals
  • Humans
  • Induced Pluripotent Stem Cells / metabolism*
  • Lamin Type A
  • Models, Biological*
  • Nuclear Proteins / metabolism*
  • Protein Precursors / metabolism*

Substances

  • Lamin Type A
  • Nuclear Proteins
  • Protein Precursors
  • prelamin A