Salvage therapy of small volume prostate cancer nodal failures: a review of the literature

Berardino De Bari; Filippo Alongi; Michela Buglione; Franco Campostrini; Alberto Briganti; Genoveffa Berardi; Giuseppe Petralia; Massimo Bellomi; Arturo Chiti; Andrei Fodor; Nazareno Suardi; Cesare Cozzarini; Di Muzio Nadia; Marta Scorsetti; Roberto Orecchia; Francesco Montorsi; Filippo Bertoni; Stefano Maria Magrini; Barbara Alicja Jereczek-Fossa

doi:10.1016/j.critrevonc.2013.11.003

Salvage therapy of small volume prostate cancer nodal failures: a review of the literature

Crit Rev Oncol Hematol. 2014 Apr;90(1):24-35. doi: 10.1016/j.critrevonc.2013.11.003. Epub 2013 Nov 21.

Authors

Berardino De Bari¹, Filippo Alongi², Michela Buglione¹, Franco Campostrini³, Alberto Briganti⁴, Genoveffa Berardi⁵, Giuseppe Petralia⁶, Massimo Bellomi⁶, Arturo Chiti⁷, Andrei Fodor⁵, Nazareno Suardi⁴, Cesare Cozzarini⁵, Di Muzio Nadia⁵, Marta Scorsetti⁸, Roberto Orecchia⁹, Francesco Montorsi⁴, Filippo Bertoni¹⁰, Stefano Maria Magrini¹, Barbara Alicja Jereczek-Fossa⁹

Affiliations

¹ Radiotherapy Department, Istituto del Radio di Brescia, University of Brescia, Brescia, Italy.
² Radiotherapy and Radiosurgery, Humanitas Cancer Center, Istituto Clinico Humanitas, Rozzano, Milan, Italy. Electronic address: filippo.alongi@cancercenter.humanitas.it.
³ Radiotherapy Department, Legnago Hospital, Legnago, Italy.
⁴ Department of Urology, Vita-Salute University San Raffaele, Milan, Italy.
⁵ Radiation Therapy, San Raffaele Scientific Institute, Milan, Italy.
⁶ Department of Radiology, European Institute of Oncology, Milan, Italy.
⁷ Nuclear Medicine, Humanitas Cancer Center, Istituto Clinico Humanitas, Rozzano, Milan, Italy.
⁸ Radiotherapy and Radiosurgery, Humanitas Cancer Center, Istituto Clinico Humanitas, Rozzano, Milan, Italy.
⁹ Department of Radiotherapy, European Institute of Oncology, Milan Italy and University of Milan, Italy.
¹⁰ Department of Radiation Therapy, Modena Hospital, Modena, Italy.

PMID: 24315428
DOI: 10.1016/j.critrevonc.2013.11.003

Abstract

New imaging modalities may be useful to identify prostate cancer patients with small volume, limited nodal relapse ("oligo-recurrent") potentially amenable to local treatments (radiotherapy, surgery) with the aim of long-term control of the disease, even in a condition traditionally considered prognostically unfavorable. This report reviews the new diagnostic tools and the main published data about the role of surgery and radiation therapy in this particular subgroup of patients.

Keywords: ADT prostate; Nodal relapse; Oligo-recurrent disease; PET prostate; Prostate cancer; Radiotherapy; SBRT; Salvage lymph node dissection; Surgery.

Publication types

Review

MeSH terms

Humans
Lymph Nodes / pathology*
Male
Multimodal Imaging*
Neoplasm Recurrence, Local / diagnosis*
Neoplasm Recurrence, Local / therapy*
Prognosis
Prostatic Neoplasms / pathology*
Salvage Therapy*