Abstract
A novel approach to prepare diarylmethyl phosphine oxides from benzyl phosphine oxides via deprotonative cross-coupling processes (DCCP) is reported. The optimization of the reaction was guided by High-Throughput Experimentation (HTE) techniques. The Pd(OAc)2/Xantphos-based catalyst enabled the reaction between benzyl diphenyl or dicyclohexyl phosphine oxide derivatives and aryl bromides in good to excellent yields (51-91%).
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Benzene Derivatives / chemical synthesis*
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Benzene Derivatives / chemistry
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Catalysis
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Hydrocarbons, Brominated / chemistry
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Molecular Structure
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Organometallic Compounds / chemistry*
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Oxides / chemical synthesis*
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Oxides / chemistry
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Palladium / chemistry*
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Phosphines / chemical synthesis*
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Phosphines / chemistry
Substances
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Benzene Derivatives
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Hydrocarbons, Brominated
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Organometallic Compounds
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Oxides
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Phosphines
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Palladium
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phosphine