Synthesis of [13C6]primaquine

H M T Bandara Herath; James D McChesney; Larry A Walker; N P Dhammika Nanayakkara

doi:10.1002/jlcr.3039

Synthesis of [13C6]primaquine

J Labelled Comp Radiopharm. 2013 Jun 15;56(7):341-3. doi: 10.1002/jlcr.3039. Epub 2013 Mar 12.

Authors

H M T Bandara Herath¹, James D McChesney, Larry A Walker, N P Dhammika Nanayakkara

Affiliation

¹ National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, MS, 38677, USA.

PMID: 24285435
DOI: 10.1002/jlcr.3039

Abstract

In support of a program to identify toxic metabolites of the antimalarial, primaquine, its [(13)C6] analog was prepared from [(13)C6] anisole in seven steps.

Keywords: 8-aminoquinoline; carbon-13; malaria; primaquine.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Antimalarials / chemical synthesis*
Carbon Isotopes / chemistry
Primaquine / chemical synthesis*

Substances

Antimalarials
Carbon Isotopes
Primaquine