Bicyclic and tetracyclic diterpenes from a Trichoderma symbiont of Taxus baccata

Phytochemistry. 2014 Jan:97:55-61. doi: 10.1016/j.phytochem.2013.10.016. Epub 2013 Nov 21.

Abstract

Trichoderma atroviridae UB-LMA is an endophytic fungus isolated from Taxus baccata trees. Liquid-state fermentation coupled to in situ solid phase extraction (SPE) was applied, and four compounds were discovered. Compounds 2-4 belong to the harziane tetracyclic diterpene family. Bicylic compound 1 may represent the biosynthetic precursor of this scarce family of compounds.

Keywords: Diterpenes; Fungal secondary metabolites; Harzianes; Trichoderma.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / pharmacology
  • Chromatography, High Pressure Liquid
  • Diterpenes / chemistry
  • Diterpenes / isolation & purification*
  • Diterpenes / pharmacology
  • Drug Screening Assays, Antitumor
  • HCT116 Cells
  • Humans
  • KB Cells
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Taxus / microbiology*
  • Trichoderma / chemistry*

Substances

  • Antineoplastic Agents
  • Diterpenes