Rational design of fluorescent light-up probes based on an AIE luminogen for targeted intracellular thiol imaging

Youyong Yuan; Ryan T K Kwok; Guangxue Feng; Jing Liang; Junlong Geng; Ben Zhong Tang; Bin Liu

doi:10.1039/c3cc47585a

Rational design of fluorescent light-up probes based on an AIE luminogen for targeted intracellular thiol imaging

Chem Commun (Camb). 2014 Jan 11;50(3):295-7. doi: 10.1039/c3cc47585a. Epub 2013 Nov 15.

Authors

Youyong Yuan¹, Ryan T K Kwok, Guangxue Feng, Jing Liang, Junlong Geng, Ben Zhong Tang, Bin Liu

Affiliation

¹ Department of Chemical and Biomolecular Engineering, 4 Engineering Drive 4, National University of Singapore, Singapore 117576.

PMID: 24244944
DOI: 10.1039/c3cc47585a

Abstract

A water-soluble fluorescent light-up bioprobe based on a luminogen with aggregation-induced emission characteristics was developed for targeted intracellular thiol imaging.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Line, Tumor
Fluorescent Dyes / chemistry*
Fluorescent Dyes / metabolism
Glutathione / chemistry
Glutathione / metabolism
Humans
Integrin alphaVbeta3 / chemistry
Integrin alphaVbeta3 / metabolism
MCF-7 Cells
Microscopy, Confocal
Oligopeptides / chemistry
Oligopeptides / metabolism
Sulfhydryl Compounds / chemistry*
Sulfhydryl Compounds / metabolism
Water / chemistry

Substances

Fluorescent Dyes
Integrin alphaVbeta3
Oligopeptides
Sulfhydryl Compounds
Water
arginyl-glycyl-aspartic acid
Glutathione