Abstract
A quinoline alkaloid 1 and five known compounds (2-6) were isolated from a novel halophilic actinomycete Nocardiopsis terrae YIM 90022, and their structures were determined by spectroscopic studies as 4-oxo-1,4-dihydroquinoline-3-carboxamide (1), p-hydroxybenzoic acid (2), N-acetyl-anthranilic acid (3), indoly-3-carboxylic acid (4), cyclo(Trp-Gly) (5) and cyclo(Leu-Ala) (6). Compound 1 was isolated from natural resources for the first time. Compounds 1 and 3 showed antimicrobial activities against some plant pathogens.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Actinobacteria
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Actinomycetales / chemistry*
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Alkaloids / chemistry
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology*
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology*
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification*
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Antifungal Agents / pharmacology*
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Bacillus subtilis / drug effects
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DNA, Bacterial
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Dipeptides
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Escherichia coli / drug effects
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Fusarium / drug effects
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Microbial Sensitivity Tests
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Nuclear Magnetic Resonance, Biomolecular
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Phylogeny
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Quinolines / chemistry
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Quinolines / isolation & purification*
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Quinolines / pharmacology*
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RNA, Ribosomal, 16S / genetics
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Soil Microbiology
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Staphylococcus aureus / drug effects
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ortho-Aminobenzoates / chemistry
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ortho-Aminobenzoates / isolation & purification
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ortho-Aminobenzoates / pharmacology
Substances
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1,4-dihydroquinoline
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4-oxo-1,4-dihydroquinoline-3-carboxamide
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Alkaloids
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Anti-Bacterial Agents
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Antifungal Agents
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DNA, Bacterial
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Dipeptides
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Quinolines
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RNA, Ribosomal, 16S
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ortho-Aminobenzoates
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leucyl-alanine
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N-acetylanthranilic acid
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tryptophylglycine