Fiber pathways of attention subnetworks revealed with tract-based spatial statistics (TBSS) and probabilistic tractography

PLoS One. 2013 Nov 4;8(11):e78831. doi: 10.1371/journal.pone.0078831. eCollection 2013.

Abstract

It has been widely accepted that attention can be divided into three subnetworks - alerting, orienting and executive control (EC), and the subnetworks of attention are linked to distinct brain regions. However, the association between specific white matter fibers and the subnetworks of attention is not clear enough. Using diffusion tensor imaging (DTI), the white matter connectivity related to the performance of attention was assessed by attention network test (ANT) in 85 healthy adolescents. Tract-based spatial statistics (TBSS) and probabilistic diffusion tractography analysis demonstrated that cerebellothalamic tract was involved in alerting, while orienting depended upon the superior longitudinal fasciculus (SLF). In addition, EC was under the control of anterior corona radiata (ACR). Our findings suggest that different fiber pathways are involved in the three distinct subnetworks of attention. The current study will yield more precise information about the structural substrates of attention function and may aid the efforts to understand the neurophysiology of several attention disorders.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Attention / physiology*
  • Brain / physiology*
  • Brain Mapping
  • Diffusion Tensor Imaging / methods
  • Female
  • Humans
  • Male
  • Nerve Fibers / physiology*
  • Nerve Net / physiology
  • Neural Pathways / physiology*
  • Neuropsychological Tests
  • Probability
  • Psychomotor Performance
  • Statistics as Topic
  • Young Adult

Grants and funding

This study was supported by National Natural Science Foundation of China (No. 30871305, 81371533) and the Graduate Independent Innovation Foundation of Shandong University (No. yzc12151). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.