Abstract
Aerial parts of Microlicia hatschbachii were extracted with hexane, and the extract was evaluated for antimicrobial activity by a broth dilution method. After phytochemical procedures: GC-MS identified aliphatic alkanes, carboxylic acids and methyl esters of long-chain fatty acids; and two diterpenoids [labd-8(17)-en-15-oic acid and labd-8(17),13-dien-15-oic acid] were identified by (1)H and (13)C NMR. The antimicrobial activity of the hexane extract could be attributed to the presence of labdanes. This identification is the first reported occurrence of labdane diterpenes in the Melastomataceae family.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Infective Agents / chemistry
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Anti-Infective Agents / isolation & purification*
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Anti-Infective Agents / pharmacology*
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Diterpenes / chemistry
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Diterpenes / isolation & purification*
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Diterpenes / pharmacology*
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Fatty Acids / chemistry
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Fatty Acids / isolation & purification*
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Fatty Acids / pharmacology*
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Gas Chromatography-Mass Spectrometry
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Hexanes / chemistry
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Melastomataceae / chemistry*
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Microbial Sensitivity Tests
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
Substances
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Anti-Infective Agents
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Diterpenes
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Fatty Acids
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Hexanes
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labd-8 (17)-en-15-oic acid
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labd-8(17),13-dien-15-oic acid
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n-hexane