Endotracheal infiltration by lymphoma is uncommon. We present 2 cases of endotracheal infiltration by non-Hodgkin lymphoma. One case had a solitary lesion in the middle trachea. Bronchoscopic biopsy of the lesion revealed diffuse large B-cell lymphoma. The tumor showed focal FDG uptake with SUVmax of 15. The other case had diffuse endotracheal lesions. Bronchoscopic biopsy revealed diffuse submucosal infiltration by natural killer/T-cell lymphoma. The thickened trachea showed diffuse FDG uptake with SUVmax of 8.4. These 2 cases indicate lymphoma should be included in the differential diagnosis of focal or diffuse endotracheal FDG accumulation.