Genomic evolution from primary breast carcinoma to distant metastasis: Few copy number changes of breast cancer related genes

Cancer Lett. 2014 Mar 1;344(1):138-146. doi: 10.1016/j.canlet.2013.10.025. Epub 2013 Oct 30.

Abstract

Cancer initiation and progression is characterized by (epi)genetic aberrations. However, little is known about the changes that occur during breast cancer metastasis. In the present study, multiplex ligation-dependent probe amplification was used to compare copy numbers of 21 established oncogenes and tumor suppressor genes between 55 primary breast cancer samples and corresponding distant metastases. Distant breast cancer metastases generally showed similar gene copy number aberrations compared to their corresponding primary tumors. The few genes that showed differences between primary tumor and metastasis (PRDM14, MED1, CCNE1, TRAF4, MTDH, CDH1) have been implicated in the development of therapy resistance.

Keywords: Breast cancer; Gene dosage; MLPA; Metastases.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Breast Neoplasms / genetics*
  • Breast Neoplasms / pathology*
  • Female
  • Gene Dosage*
  • Genes, Tumor Suppressor
  • Genomics
  • Humans
  • Middle Aged
  • Multiplex Polymerase Chain Reaction
  • Neoplasm Invasiveness / genetics*
  • Neoplasm Metastasis / genetics*
  • Oncogenes / genetics