Abstract
Sixteen patients with metastatic malignant melanoma were treated with poly(I,C)-LC 5 mg/m2 twice weekly by intravenous injection. No antitumor responses occurred. Fever (frequently greater than 40 degrees C) and fatigue were dose limiting toxicities. One patient developed a fever of 42.2 degrees C when poly(I,C)-LC was given on 2 consecutive days. Interferon was consistently detected in the serum 8 h after a single injection of poly(I,C)-LC (median titer 199 U/ml). No enhancement of interferon induction was detected on the second day when poly(I,C)-LC was given on 2 consecutive days.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Aged
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Antineoplastic Agents / administration & dosage
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Antineoplastic Agents / therapeutic use
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Antineoplastic Agents / toxicity
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Carboxymethylcellulose Sodium / administration & dosage
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Carboxymethylcellulose Sodium / therapeutic use*
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Carboxymethylcellulose Sodium / toxicity
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Drug Evaluation
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Fatigue / chemically induced
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Female
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Fever / chemically induced
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Humans
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Interferons / blood
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Male
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Melanoma / drug therapy*
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Melanoma / immunology
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Melanoma / secondary
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Methylcellulose / analogs & derivatives*
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Middle Aged
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Poly I-C / administration & dosage
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Poly I-C / therapeutic use*
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Poly I-C / toxicity
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Polylysine / administration & dosage
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Polylysine / therapeutic use*
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Polylysine / toxicity
Substances
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Antineoplastic Agents
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Polylysine
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poly ICLC
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Methylcellulose
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Interferons
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Carboxymethylcellulose Sodium
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Poly I-C