TERT promoter mutations rather than methylation are the main mechanism for TERT upregulation in adult gliomas

Acta Neuropathol. 2013 Dec;126(6):939-41. doi: 10.1007/s00401-013-1203-9. Epub 2013 Oct 31.

Authors

Hideyuki Arita¹, Yoshitaka Narita, Hirokazu Takami, Shintaro Fukushima, Yuko Matsushita, Akihiko Yoshida, Yasuji Miyakita, Makoto Ohno, Soichiro Shibui, Koichi Ichimura

Affiliation

¹ Department of Neurosurgery and Neuro-Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

PMID: 24174165
DOI: 10.1007/s00401-013-1203-9

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Brain Neoplasms / genetics*
Glioma / genetics*
Humans
Methylation
Mutation*
Promoter Regions, Genetic*
Telomerase / genetics*
Up-Regulation*

Substances

TERT protein, human
Telomerase