The role of protein kinase CK2 in glioblastoma development

Clin Cancer Res. 2013 Dec 1;19(23):6335-7. doi: 10.1158/1078-0432.CCR-13-2478. Epub 2013 Oct 28.

Abstract

Glioblastoma is the most prevalent and malignant primary brain tumor in adults, and its response to current therapies is limited. Protein kinase CK2 is overexpressed in glioblastoma and regulates glioblastoma cell survival, proliferation, and migration and brain tumorigenesis. Targeting CK2 for glioblastoma treatment may benefit patients with glioblastoma.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacology*
  • Brain Neoplasms / enzymology*
  • Casein Kinase II / genetics
  • Female
  • Glioblastoma / enzymology*
  • Humans
  • Naphthyridines / pharmacology*
  • Phenazines
  • Signal Transduction*

Substances

  • Antineoplastic Agents
  • Naphthyridines
  • Phenazines
  • silmitasertib
  • CSNK2A1 protein, human
  • Casein Kinase II