Sertoli-Leydig cell tumor of the ovary with alpha-fetoprotein production

Arch Pathol Lab Med. 1986 Jan;110(1):65-8.

Abstract

A case of poorly differentiated Sertoli-Leydig cell tumor with elevated serum alpha-fetoprotein (AFP) levels occurred in a 17-year-old girl. No germ cell component and no heterologous elements were identified, but a retiform pattern was present. Immunohistochemical studies demonstrated immunoreactivity for AFP and testosterone in Leydig's cells only. Secretion of AFP by Sertoli-Leydig cell tumors has rarely been mentioned previously, and its mechanism is difficult to explain. Non-germ cell tumors must be considered in the differential diagnosis of ovarian tumors with elevated serum AFP levels.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Female
  • Histocytochemistry
  • Humans
  • Immunoenzyme Techniques
  • Leydig Cell Tumor / metabolism*
  • Leydig Cell Tumor / pathology
  • Leydig Cell Tumor / ultrastructure
  • Ovarian Neoplasms / metabolism*
  • Ovarian Neoplasms / pathology
  • Ovarian Neoplasms / ultrastructure
  • Sertoli Cell Tumor / metabolism*
  • Sertoli Cell Tumor / pathology
  • Sertoli Cell Tumor / ultrastructure
  • alpha-Fetoproteins / metabolism*

Substances

  • alpha-Fetoproteins