Reply: To PMID 23722610

J Acquir Immune Defic Syndr. 2014 Mar 1;65(3):e124-5. doi: 10.1097/QAI.0000000000000042.

Abstract

The reviewer points out correctly that we used a correlational approach and therefore cannot determine causality or establish the direction of the significant relationships observed between some of the sleep indices and cognitive performance in the HIV-positive individuals. Given that this is one of the first studies exploring how sleep in HIV-positive individuals might impact cognitive performance, we believe that it is an acceptable scientific contribution to conduct an exploratory analysis to highlight any potential relationships. If there are acceptable relationships, then, as the reviewer mentions, one could expand and explore the underlying mechanisms for this relationship using an experimental approach. This paper illustrates possible relationships between cognition and sleep in HIV participants. As mentioned in the manuscript, we hope that future studies will be conducted that can confirm and/or expand upon these findings.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Cognition Disorders / epidemiology*
  • Female
  • HIV Infections / complications*
  • Humans
  • Male
  • Sleep Wake Disorders / complications*
  • Sleep Wake Disorders / epidemiology*