Abstract
Ehrlichia chaffeensis is an obligately intracellular gram negative bacterium with a small genome that thrives in mammalian mononuclear phagocytes by exploiting eukaryotic processes. Herein, we discuss the latest findings on moonlighting tandem repeat protein effectors and their secretion mechanisms, and novel molecular interkingdom interactions that provide insight into the intracellular pathobiology of ehrlichiae.
Keywords:
Effector; Ehrlichia; Human monocytotropic ehrlichiosis; Moonlighting protein; Nucleomodulin; Post translational modification; Tandem repeat protein; Type 1 secretion system; Zoonosis.
Copyright © 2013 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Ankyrins / metabolism
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Bacterial Proteins / metabolism*
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Bacterial Secretion Systems
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Cell Nucleus / metabolism
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Ehrlichia / physiology*
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Ehrlichiosis / metabolism*
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Ehrlichiosis / microbiology*
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Gene Expression Regulation, Bacterial
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Genome, Bacterial
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Host-Pathogen Interactions* / immunology
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Humans
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Intracellular Space / immunology
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Intracellular Space / microbiology
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Phagocytes / metabolism*
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Phagocytes / microbiology*
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Protein Binding
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Protein Transport
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Transient Receptor Potential Channels / metabolism
Substances
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Ankyrins
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Bacterial Proteins
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Bacterial Secretion Systems
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Transient Receptor Potential Channels