Ehrlichia moonlighting effectors and interkingdom interactions with the mononuclear phagocyte

Microbes Infect. 2013 Dec;15(14-15):1005-16. doi: 10.1016/j.micinf.2013.09.011. Epub 2013 Oct 18.

Abstract

Ehrlichia chaffeensis is an obligately intracellular gram negative bacterium with a small genome that thrives in mammalian mononuclear phagocytes by exploiting eukaryotic processes. Herein, we discuss the latest findings on moonlighting tandem repeat protein effectors and their secretion mechanisms, and novel molecular interkingdom interactions that provide insight into the intracellular pathobiology of ehrlichiae.

Keywords: Effector; Ehrlichia; Human monocytotropic ehrlichiosis; Moonlighting protein; Nucleomodulin; Post translational modification; Tandem repeat protein; Type 1 secretion system; Zoonosis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Ankyrins / metabolism
  • Bacterial Proteins / metabolism*
  • Bacterial Secretion Systems
  • Cell Nucleus / metabolism
  • Ehrlichia / physiology*
  • Ehrlichiosis / metabolism*
  • Ehrlichiosis / microbiology*
  • Gene Expression Regulation, Bacterial
  • Genome, Bacterial
  • Host-Pathogen Interactions* / immunology
  • Humans
  • Intracellular Space / immunology
  • Intracellular Space / microbiology
  • Phagocytes / metabolism*
  • Phagocytes / microbiology*
  • Protein Binding
  • Protein Transport
  • Transient Receptor Potential Channels / metabolism

Substances

  • Ankyrins
  • Bacterial Proteins
  • Bacterial Secretion Systems
  • Transient Receptor Potential Channels