Abstract
Fifteen patients with advanced squamous cell carcinoma of the anal canal were treated with a combination of bleomycin, vincristine, and high-dose methotrexate (BOM) with leucovorin rescue. Three out of twelve patients with measurable disease had objective responses of 1, 2, and 5 months. Five of the fifteen patients had severe or life-threatening complications as a result of this treatment regimen. The narrow therapeutic index of the BOM therapy makes it a less than ideal drug combination for the treatment of advanced squamous cell carcinoma of the anal canal.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Antineoplastic Combined Chemotherapy Protocols / toxicity*
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Anus Neoplasms / drug therapy*
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Anus Neoplasms / pathology
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Bleomycin / administration & dosage
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Carcinoma, Squamous Cell / drug therapy*
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Carcinoma, Squamous Cell / pathology
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Drug Evaluation
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Female
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Follow-Up Studies
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Humans
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Leucovorin / administration & dosage*
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Male
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Methotrexate / administration & dosage
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Middle Aged
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Neoplasm Metastasis
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Vincristine / administration & dosage
Substances
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Bleomycin
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Vincristine
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Leucovorin
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Methotrexate