Wiping DNA methylation: Wip1 regulates genomic fluidity on cancer

Martin Muñoz-Lopez; Pedro P Medina; Jose L Garcia-Perez

doi:10.1016/j.ccr.2013.10.002

Wiping DNA methylation: Wip1 regulates genomic fluidity on cancer

Cancer Cell. 2013 Oct 14;24(4):405-7. doi: 10.1016/j.ccr.2013.10.002.

Authors

Martin Muñoz-Lopez¹, Pedro P Medina, Jose L Garcia-Perez

Affiliation

¹ Department of Human DNA Variability, University of Granada, GENYO: Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS Granada, Avenue de la Ilustracion, 114, 18016 Granada, Spain.

PMID: 24135277
DOI: 10.1016/j.ccr.2013.10.002

Abstract

Wip1 phosphatase plays an important role in cancer by inactivating p53 and INK4a/ARF pathways. In this issue of Cancer Cell, Filipponi and colleagues further connect the oncogenic role of Wip1 with heterochromatin dynamics, transposable element expression, and a mutation-prone environment that may enhance heterogeneity and ultimately contribute to tumor evolution.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Ataxia Telangiectasia Mutated Proteins / metabolism*
BRCA1 Protein / metabolism*
DNA Methylation*
Heterochromatin / metabolism*
Humans
Male
Phosphoprotein Phosphatases / metabolism*
Protein Phosphatase 2C

Substances

BRCA1 Protein
Heterochromatin
ATM protein, human
Ataxia Telangiectasia Mutated Proteins
Atm protein, mouse
PPM1D protein, human
Phosphoprotein Phosphatases
Ppm1d protein, mouse
Protein Phosphatase 2C