Identification of 6-demethoxy-6-methylgeldanamycin and its implication of geldanamycin biosynthesis

J Antibiot (Tokyo). 2014 Feb;67(2):183-5. doi: 10.1038/ja.2013.94. Epub 2013 Oct 9.

Authors

Affiliation

¹ Key Laboratory of Biotechnology of Antibiotics of Ministry of Health, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

PMID: 24105607
DOI: 10.1038/ja.2013.94

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antibiotics, Antineoplastic / chemistry*
Antibiotics, Antineoplastic / metabolism*
Benzoquinones / chemistry*
Benzoquinones / isolation & purification
Benzoquinones / metabolism*
Benzoquinones / pharmacology*
Cell Line, Tumor
Drug Discovery
Hep G2 Cells
Humans
Lactams, Macrocyclic / chemistry*
Lactams, Macrocyclic / isolation & purification
Lactams, Macrocyclic / metabolism*
Lactams, Macrocyclic / pharmacology*
Molecular Conformation
Molecular Structure
Streptomyces / metabolism

Substances

6-demethoxy-6-methylgeldanamycin
Antibiotics, Antineoplastic
Benzoquinones
Lactams, Macrocyclic
tanespimycin
geldanamycin