Sex-specific effects of cis-regulatory variants in Drosophila melanogaster

Genetics. 2013 Dec;195(4):1419-22. doi: 10.1534/genetics.113.156331. Epub 2013 Oct 4.

Abstract

Sexual dimorphism at the level of gene expression is common and well documented, but much less is known about how different cis-regulatory alleles interact with the different trans-regulatory environments present in males and females. Here we show that sex-specific effects of cis-regulatory variants are common in Drosophila.

Keywords: allele-specific expression; epistasis; gene regulation; imprinting; trans-regulation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Chromosomes, Insect / genetics
  • Drosophila Proteins / genetics*
  • Drosophila Proteins / metabolism
  • Drosophila melanogaster / genetics*
  • Epistasis, Genetic*
  • Female
  • Genomic Imprinting*
  • Male
  • Sex Characteristics*
  • Sex Chromosomes / genetics
  • Transcription, Genetic

Substances

  • Drosophila Proteins