Echocardiographic changes and treatment goal rates after a 6-month combined treatment with amlodipine and losartan: a validation study in Andean countries (METAL study)

Ther Adv Cardiovasc Dis. 2013 Oct;7(5):237-45. doi: 10.1177/1753944713506507. Epub 2013 Oct 4.

Abstract

Background: The extent to which treatment with amlodipine/losartan may help patients and their doctors from Andean countries to reach their treatment goals remains unknown.

Methods: We conducted a quasi-experimental, validation study in which patients with primary, uncomplicated hypertension received open-label, fixed combination therapy with amlodipine/losartan 5/50 mg or 5/100 mg according to their baseline blood pressure (BP). The primary outcome was echocardiographic reduction of left ventricular mass (LMV) after 6 months of treatment. Secondary outcomes were changes in BP, uricemia and albuminuria from baseline. We defined patients with adequately controlled hypertension as those with decreases in at least three out of these four variables.

Results: From 109 eligible patients with hypertension, 99 started the protocol (70 under the low-dose combination). Echocardiography indices had mutual correlation and contributed independently to the primary outcome (Cronbach's α index = 0.66). Intention-to-treat analysis showed that 60 patients [60.6%, 95% confidence interval (CI) 50.3-70.3] had reduced LVM. Echocardiographic changes were not associated with dose levels. Favorable changes in BP, uricemia and microabuminuria were seen in 77, 64 and 76 patients respectively. After 6 months there were 64 (95% CI 54-74%) patients with adequately controlled hypertension.

Conclusion: Every two of three patients of this sample of Andean countries reached adequate control after 6 months of combined antihypertensive treatment with amlodipine/losartan.

Keywords: amlodipine; combined therapy; hypertension; losartan; ventricular hypertrophy.

Publication types

  • Comparative Study
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't
  • Validation Study

MeSH terms

  • Aged
  • Albuminuria / drug therapy
  • Amlodipine / administration & dosage
  • Amlodipine / therapeutic use*
  • Antihypertensive Agents / administration & dosage
  • Antihypertensive Agents / therapeutic use*
  • Blood Pressure / drug effects
  • Dose-Response Relationship, Drug
  • Drug Combinations
  • Echocardiography
  • Female
  • Follow-Up Studies
  • Humans
  • Hypertension / drug therapy*
  • Hyperuricemia / drug therapy
  • Losartan / administration & dosage
  • Losartan / therapeutic use*
  • Male
  • Middle Aged
  • South America
  • Time Factors
  • Treatment Outcome

Substances

  • Antihypertensive Agents
  • Drug Combinations
  • Amlodipine
  • Losartan