The Semaphorin 3E/PlexinD1 axis regulates macrophage inflammation in obesity

Cell Metab. 2013 Oct 1;18(4):461-2. doi: 10.1016/j.cmet.2013.09.011.

Abstract

Increased accumulation of adipose tissue macrophages in obesity propagates chronic inflammation that is closely associated with insulin resistance and type 2 diabetes. Semaphorin 3E, a guidance molecule for neurons, takes on a new role in obesity by directing the recruitment of macrophages in visceral adipose tissue (Shimizu et al., 2013).

Publication types

  • Comment

MeSH terms

  • Animals
  • Diet, High-Fat*
  • Inflammation / metabolism*
  • Intracellular Signaling Peptides and Proteins
  • Male
  • Membrane Glycoproteins / metabolism*
  • Nerve Tissue Proteins / metabolism*
  • Obesity / metabolism*
  • Semaphorins / metabolism*

Substances

  • Intracellular Signaling Peptides and Proteins
  • Membrane Glycoproteins
  • Nerve Tissue Proteins
  • Plxnd1 protein, mouse
  • Semaphorins