Abstract
Epstein-Barr virus (EBV) is a vaccine/immunotherapy target due to its association with several human malignancies. EBNA-1 is an EBV protein consistently expressed in all EBV-associated cancers. Herein, EBNA-1-specific T cell epitopes were evaluated after AdC-rhEBNA-1 immunizations in chronically lymphocryptovirus-infected rhesus macaques, an EBV infection model. Preexisting rhEBNA-1-specific responses were augmented in 4/12 animals, and new epitopes were recognized in 5/12 animals after vaccinations. This study demonstrated that EBNA-1-specific T cells can be expanded by vaccination.
Publication types
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Research Support, American Recovery and Reinvestment Act
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Epitope Mapping
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Epitopes, T-Lymphocyte / chemistry
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Epitopes, T-Lymphocyte / genetics
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Epitopes, T-Lymphocyte / immunology
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Epstein-Barr Virus Nuclear Antigens / administration & dosage
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Epstein-Barr Virus Nuclear Antigens / chemistry
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Epstein-Barr Virus Nuclear Antigens / genetics
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Epstein-Barr Virus Nuclear Antigens / immunology*
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Female
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Herpesviridae Infections / drug therapy
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Herpesviridae Infections / immunology
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Herpesviridae Infections / veterinary*
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Herpesviridae Infections / virology
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Lymphocryptovirus / genetics
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Lymphocryptovirus / immunology*
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Macaca mulatta* / genetics
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Macaca mulatta* / immunology
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Macaca mulatta* / virology
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Male
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Primate Diseases / drug therapy
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Primate Diseases / immunology*
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Primate Diseases / virology
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T-Lymphocytes / immunology*
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T-Lymphocytes / virology
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Vaccination
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Viral Vaccines / administration & dosage
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Viral Vaccines / chemistry
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Viral Vaccines / genetics
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Viral Vaccines / immunology
Substances
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Epitopes, T-Lymphocyte
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Epstein-Barr Virus Nuclear Antigens
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Viral Vaccines
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EBV-encoded nuclear antigen 1